Persistent Pupillary Membranes is a condition that arises as a result of the presence of tissues in the eye, which are actually remnants of blood vessels that provide nutrients to the lens of the eye during embryonic growth. In normal development, these tissues disappear when the newborn puppy is 4 to 5 weeks old. The degree of vision interference is dependent on where the tissues are located within the eyes. Some pupillary membranes may be stretched between iris to the pupil, from the iris to the lens, from the iris to the cornea, or the strands may form a layer in the anterior part of the eye. The occurrence of Persistent Pupillary Membrane is considered to be an inherited trait. PPM can affect any breed of dog however it is most commonly observed in the Pembroke, Chowchow, Basenji, Cardigan Welsh Corgi, and Mastiff.

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