Ferrets suffering from adrenal disease commonly experience hair loss that usually starts at or near the animal’s tail and progressing toward the head. Female ferrets with adrenal disease seem to be in heat, with their vulva prominently enlarged. On other hand, affected male ferret have find it difficult to urinate as a result of an enlarged prostrate. Some males may also exhibit increased aggressive and/or sexual behavior. Some ferrets will become weak and lethargic; and some lose their muscle tone. For the most part, these symptoms are brought by sexual hormones produced by the adrenal glands. These hormones include estrogen, progesterone, and testosterone. Normally, the adrenal glands don’t produce sexual hormones in disease-free ferrets. Over 50% of ferrets in the US will manifest symptoms of adrenal disease as adults, most between 3-6 weeks of age. A genetic factor is likely to be involved. Your animal hospital University Heights may make a tentative diagnosis based on manifested symptoms and medical history. Further tests may be recommended to confirm the initial diagnosis.